Manual AT Dissolution Tester Apparatus Sotax
The AT is the 4th generation of SOTAX dissolution baths and the heart of the Xtend™ Dissolution Line. Whether used as a manual apparatus or as the core component in an automated dissolution system – the AT has been designed for the most demanding environments.
Built on the success of preceding SOTAX dissolution systems, the AT can be flexibly configured for USP 1,2,5,6 and non-compliant stirring dissolution methods. Its unique design combines robust quality components with state-of-the-art technology to guarantee reproducible testing conditions, day after day. Depending on the required automation level, the AT can be flexibly extended with additional Xtend™ modules – making method transfer for increased throughput requirements easier than ever.
AT Manual Dissolution SystemThe new state-of-the-art standard : Xtend™ Dissolution Line – modular, scalable, future-proofFulfills all Pharmacopeia requirements for USP 1,2,5,6 dissolution methodsInnovative circular bath design for perfect visibilityAutoCompliance™ by designLarge touch screen, 100 methods storage, users rights, USB and LAN interface
100% visibility and CenterView™ video monitoringThe innovative circular design of the dissolution bath opens up a new dimension of observation possibilities for R&D visualization and OOS troubleshooting. Understanding the release characteristics of formulations requires full visibility of samples during the dissolution test. Depending on your observation needs, the circular AT bath allows visual observation of each vessel from the outside and additionally from the inside using video monitoring. To view the behavior of samples from the bottom, an optional mirrored base plate is available.Precise temperature control and easy handling & cleaningThe innovative circular design of the dissolution bath sets new standards for precise, quick and easy operation. Like its predecessor models, the AT dissolution bath has been optimized for ideal water circulation to ensure extremely high temperature homogeneity during the test.
Compliance by designThe AT dissolution apparatus fully complies with all harmonized Pharmacopeia requirements and features “built-in” compliance without any adjustment. The proven SOTAX AutoCompliance™ concept with fixed shaft height and vessel positioning guarantees 100% compliance without requiring time-consuming adjustments by the operator. For fast change-overs, quick-lock systems and a vertical bath closing mechanism ( manual or motorized ) provide for simple handling processes.
Auto-centering vessels : Time-consuming vessel set-up is unknown with the AT’s auto-centering quick-lock system. Locking rings, which are fixed on the base plate, guarantee highly accurate vessel centering and allow analysts to insert or remove vessels within seconds. Each vessel is certified and closed with an individual cover limiting evaporation.
Fixed shaft height : Proven to have the lowest wobble ratings in the industry, the AT incorporates the same shaft design as previous SOTAX dissolution baths. All shafts are self-centering and no adjustment of shaft height is required – maintaining the highest level of precision while making changeovers fast and simple.
Fully documented qualification : The AT has been designed to facilitate highly accurate mechanical calibration anytime. Using the innovative Mechanical Qualification Device ( MQD ), all required procedures and measurements can be easily performed and results are automatically documented according to the current FDA guidelines on enhanced mechanical qualification.
Flexibility maximized - suited for all dosage formsLarge inlet dimensions provide for a wide variety of tablet and sinker types to be introduced manually or automatically.From standard tablets to capsules with large sinkers – the dissolution bath is capable of handling virtually all dosage forms.Samples are protected from media before test start. As the inlets are closed during the test, media evaporation is prevented.
Flexibility maximized - various vessel stylesFor full flexibility, the dissolution apparatus can be operated with various vessel types. The bath accommodates a broad variety of different vessel styles – from certified standard glass vessels to polycarbonate or low actinic glass vessels, 1 or 2 liter vessels, mini vessels, immersion cell vessel, peak vessels, and China vessels.
Flexibility maximized - USP 1,2,5,6 methods and moreDeveloped for USP 1,2,5,6 methods, the dissolution apparatus allows testing with different compliant and also non-compliant stirrer designs: Basket, Paddle, Paddle over disk, Rotating Cylinder, Extraction Cell, Mini Paddle, China Paddle, Stationary Basket, Intrinsic Dissolution. All parts are made of high quality material, are serialized and certified.